Development, in-vitro characterization and ex-vivo permeation study of metronidazole loaded mucoadhesive ethosomal gel for the local treatment of oral cavity infection

The present study deals with the formulation, characterization of Metronidazole loaded ethosomal gel for treating oral infection. system comprises 2-5% phospholipids, 20-50% ethanol, 10% propylene glycol, cholesterol and v/v aqueous phase. Cold method was applied to develop ethosome. prepared ethosome evaluated vesicle size, entrapment efficiency,The Optimized Ethosome formulation converted in gel. further pH, Drug content, mucoadhesive strength ex-vivo permeation study. size MEF8 showed lowest value 324±1.32 µm. Formulation maximum efficiency 86.11±0.11%. MEG8 formulated from optimized drug release 99.35% 12 hr mucosa found be 1200µg/ml at 30minutes as compared pure drug.